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L-NAME hydrochloride

A pro-drug of the NOS inhibitor L- NG-Nitro-L-arginine
Catalog #: 2356
SKU-Size Size Price Qty
2356-100 100 mg
2356-500 500 mg
2356-1000 1 g
More Sizes Get Quote

Product Details

Alternate Name NG-Nitro-L-arginine methyl ester hydrochloride
Appearance White solid
CAS # 51298-62-5
Molecular Formula C₇H₁₅N₅O₄.HCl
Molecular Weight 269.69
Purity ≥98%
Solubility DMSO (~ 5 mg/ml) or H2O (~50 mg/ml)
InChi InChI=1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
PubChem CID 135193
MDL Number MFCD00039052
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A pro-drug of L- NG-Nitro-L-arginine (L-NOARG). Hydrolysis of the methyl ester of L-NAME by cellular esterases converts it into a fully functional L-NOARG that exhibits some selectivity for inhibition of neuronal and endothelial NOS isoforms (Ki values of 15 nM, 39 nM, and 4.4 µM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively). L-NAME inhibits cGMP formation in endothelial cells with an IC₅₀ of 3.1 µM (in the presence of 30 µM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC₅₀ of 0.54 µM.

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Colin Venter. Co-culture of pro-inflammatory macrophages and myofibroblasts: Evaluating morphological phenotypes and screening the effects of signaling pathway inhibitors. Physiol Rep. Jan 2021. 33463904.