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L-Methionine γ-Lyase, Pseudomonas putida recombinant

≥90% Pure Active Recombinant L-Methionine γ-Lyase which plays a central role in sulfur amino acid metabolism
Catalog #: 7848
SKU-Size Size Price Qty
7848-100 100 μg
$100.00
7848-500 500 μg
$310.00
More Sizes Get Quote

Product Details

Alternate Name L-Methionine-α-deamino-γ-mercaptomethane-Lyase, Methioninase, METase, MGL, mdeA
Gene Symbol mdeA
Accession # P13254
Source E. coli
Appearance Lyophilized
Physical Form Description Lyophilized from 10 mg/ml in 20 mM potassium phosphate, 150 mM NaCl, pH 8.3.
Molecular Weight 47.1 kDa (1-398 aa, NT Poly-His Tag)
Purity by SDS-PAGE ≥90%
Biological Activity ≥ 0.5 U/mg.
Reconstitution Instructions Briefly spin down and reconstitute in water or phosphate buffer.
Amino Acid Sequence 1-398 aa, NT Poly-His Tag
Handling Centrifuge the vial prior to opening.
Storage Conditions –20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Methionine gamma-lyase (EC 4.4.1.11) from Pseudomonas putida is a PLP-dependent enzyme which plays a central role in sulfur amino acid metabolism. METase catalyzes the α, γ-elimination of methionine to α-ketobutyrate, methanethiol, and ammonia. METase also catalyzes the α, γ-elimination of other sulfur containing amino acids, such as homocysteine, cysteine. Because of its ability to deplete methionine, METase has been considered as a viable component of cancer therapeutics against methionine-dependent tumor cells. METase has also been utilized to design drug targets for the infectious diseases caused by parasitic protozoa and anaerobic periodontal bacteria.


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