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L-α-Hydroxyglutaric Acid Disodium Salt

L-α-Hydroxyglutaric Acid increases in 2-hydroxyglutaric aciduria.
Catalog #: B2812
SKU-Size Size Price Qty
B2812-5 5 mg
B2812-25 25 mg
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Product Details

Alternate Name disodium;(2S)-2-hydroxypentanedioate, Sodium (S)-2-hydroxypentanedioate, Disodium (S)-2-hydroxyglutarate, (S)-2-Hydroxypentanedioic acid disodium salt
Appearance Crystalline solid
CAS # 63512-50-5
Molecular Formula C₅H₆Na₂O₅
Molecular Weight 192.08
Purity ≥95%
Solubility ~10 mg/ml in PBS
SMILES C(CC(=O)[O-])C(C(=O)[O-])O.[Na+].[Na+]
InChi InChI=1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1
PubChem CID 56845267
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


L-α-Hydroxyglutaric Acid is metabolized to 2-oxoglutarate or α-ketoglutarate by L-2-hydroxyglutarate dehydrogenase. Rare defects in L-2-hydroxyglutarate dehydrogenase cause a neurometabolic disorder characterized by 2-hydroxyglutaric aciduria. High concentrations of L-α-Hydroxyglutaric Acid inhibit histone lysine demethylases, which might promote oncogenesis. 2-hydroxyglutarate can be used in the collection buffer to improve HIF-1α recovery from tumor specimens.

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