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L-Asparaginase

It is an anti-tumor agent derived from E.coli, which can inhibit the growth of malignant cells
Catalog #: P1321

In stock

SKU-Size Size Price Qty
P1321-500 500 IU
$115.00
P1321-2500 2500 IU
$225.00
P1321-10000 10,000 IU
$595.00
More Sizes Get Quote

Product Details

Alternate Name L-asparagine amidohydrolase, L-ASNase, Escherichia coli L-asparaginase, L-ASP, Colaspase, ASP-1, asparaginase II
Gene Symbol ansA
Accession # P0A962
Source E.coli ASI.357
Appearance Sterile Filtered White lyophilized (freeze-dried) powder
Physical Form Description The enzyme was lyophilized with no additives
Purity by SDS-PAGE ≥ 96.0%
Biological Activity One IU of L- Asparaginase is defined as that amount of enzyme required to generate 1 µmol of ammonia per minute at pH 7.3 and 37°C.
Reconstitution Instructions It is recommended to reconstitute the lyophilized L-Asparaginase in 18M-cm H2O at 1mg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

L-Asparaginase is an enzyme that depletes L-Asparagine "an important nutrient for cancer cells" resulting in cancer/tumor cell starvation. L-asparaginase is an anti-tumor agent derived from E.coli, which can inhibit the growth of malignant cells. It is used mainly for the induction of remission in acute lymphoblastic leukemia. Because of the lymph node origin of malignant B cells in Multiple Myeloma, L-Asparagine is an essential amino acid for their cell metabolism, and, consequently, L-Asparaginase may be of value in managing the disease. The rationale behind asparaginase is that it takes advantage of the fact that all cells are unable to synthesize the non-essential amino acid asparagine whereas normal cells are able to make their own asparagine. These leukemic cells depend on circulating asparagine. Asparaginase however catalyzes the conversion of L-asparagine to aspartic acid and ammonia. This deprives the leukemic cell of circulating asparagine.


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