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KU-0060648

A potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and HDR enhancer
Catalog #: B1115
SKU-Size Size Price Qty
B1115-5 5 mg
$135.00
B1115-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name  4-Ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide
Appearance Off-white solid
CAS # 881375-00-4
Molecular Formula C₃₃H₃₄N₄O₄S
Molecular Weight 582.71
Purity ≥98% by HPLC
Solubility Aqueous HCl (>50 mg/ml)
SMILES CCN1CCN(CC1)CC(=O)NC2=C3C4=CC=CC=C4SC3=C(C=C2)C5=CC=CC6=C5OC(=CC6=O)N7CCOCC7
InChi InChI=1S/C33H34N4O4S/c1-2-35-12-14-36(15-13-35)21-29(39)34-26-11-10-23(33-31(26)25-6-3-4-9-28(25)42-33)22-7-5-8-24-27(38)20-30(41-32(22)24)37-16-18-40-19-17-37/h3-11,20H,2,12-19,21H2,1H3,(H,34,39)
InChi Key AATCBLYHOUOCTO-UHFFFAOYSA-N
PubChem CID 11964036
MDL Number MFCD18089827
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

KU-0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC₅₀ = 8.6 nM). Displays 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases.  Inhibits proliferation of MCF7 cells in vitro and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency, and attenuates nonhomologous end-joining (NHEJ).


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