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Ku-60019

A potent and reversible ATM kinase inhibitor
Catalog #: 9572
SKU-Size Size Price Qty
9572-5 5 mg
$95.00
9572-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name (2R,​6S)​-2,​6-​dimethyl-​N-​[5-​[6-​(4-​morpholinyl)​-​4-​oxo-​4H-​pyran-​2-​yl]​-​9H-​thioxanthen-​2-​yl]​-​4-​morpholineacetamide
Appearance Light yellow to yellow solid
CAS # 925701-49-1
Molecular Formula C₃₀H₃₃N₃O₅S
Molecular Weight 547.67
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES CC1CN(CC(O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C=CC=C4C3)C5=CC(=O)C=C(O5)N6CCOCC6
InChi InChI=1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+
InChi Key SCELLOWTHJGVIC-BGYRXZFFSA-N
PubChem CID 15953870
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC₅₀ = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro.


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