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KPT-335

A selective CRM1 inhibitor
Catalog #: B2127

In stock

SKU-Size Size Price Qty
B2127-1 1 mg
$95.00
B2127-5 5 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyridin-2-ylprop-2-enehydrazide; Verdinexor
Appearance Crystalline solid
CAS # 1392136-43-4
Molecular Formula C₁₈H₁₂F₆N₆O
Molecular Weight 442.32
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
SMILES C1=CC=NC(=C1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
InChi InChI=1S/C18H12F6N6O/c19-17(20,21)12-7-11(8-13(9-12)18(22,23)24)16-26-10-30(29-16)6-4-15(31)28-27-14-3-1-2-5-25-14/h1-10H,(H,25,27)(H,28,31)/b6-4-
InChi Key OPAKEJZFFCECPN-XQRVVYSFSA-N
PubChem CID 71492799
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

KPT-335 is a potent and selective CRM1 (XPO1) inhibitor that acts as an antiviral drug. KPT-335 works to block CRM1 mediated export of viral proteins critical for RSV and influenza pathogenesis as well as to repress nuclear factor κB (NF-κB) activation, thus reducing cytokine production and eliminating virus-associated immunopathology. 


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