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KPT-251

A selective CRM1 inhibitor
Catalog #: B2124

In stock

SKU-Size Size Price Qty
B2124-5 5 mg
$135.00
B2124-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name (Z)-2-(2-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole
Appearance White solid
CAS # 1388841-50-6
Molecular Formula C₁₄H₇F₆N₅O
Molecular Weight 375.23
Purity ≥98% by HPLC
Solubility DMSO (~25 mg/ml)
SMILES C1=C(C=C(C=C1C(F)(F)F)C(F)(F)F)C2=NN(C=N2)C=CC3=NN=CO3
InChi InChI=1S/C14H7F6N5O/c15-13(16,17)9-3-8(4-10(5-9)14(18,19)20)12-21-6-25(24-12)2-1-11-23-22-7-26-11/h1-7H/b2-1-
InChi Key LDFXTRYMMZGKIC-UPHRSURJSA-N
PubChem CID 57519758
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

KPT-251 is a selective inhibitor of nuclear export proteins. It covalently binds to Cys528 in the nuclear export signal-binding groove of CRM1 (exportin 1), inhibiting its nuclear export function. KPT-251 displays potent antileukemic activity with negligible toxicity to normal hematopoietic cells when administered orally to immunodeficient mice engrafted with human AML cells.


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