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KPT-185

A selective CRM1 inhibitor
Catalog #: B2122

In stock

SKU-Size Size Price Qty
B2122-5 5 mg
$115.00
B2122-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name Propan-2-yl (Z)-3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]prop-2-enoate
Appearance Crystalline solid
CAS # 1333151-73-7
Molecular Formula C₁₆H₁₆F₃N₃O₃
Molecular Weight 355.31
Purity ≥98% by HPLC
Solubility DMSO (>15 mg/ml)
SMILES CC(C)OC(=O)C=CN1C=NC(=N1)C2=CC(=CC(=C2)OC)C(F)(F)F
InChi InChI=1S/C16H16F3N3O3/c1-10(2)25-14(23)4-5-22-9-20-15(21-22)11-6-12(16(17,18)19)8-13(7-11)24-3/h4-10H,1-3H3/b5-4-
InChi Key NLNGWFLRRRYNIL-PLNGDYQASA-N
PubChem CID 53495165
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

KPT-185 is a selective and irreversible inhibitor of chromosome maintenance protein 1 (CRM1). It displays potent antiproliferative properties at submicromolar concentrations (IC₅₀ = 100-500 nM), induces apoptosis (average 5-fold increase), cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts.


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