Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]


A selective CRM1 inhibitor
Catalog #: B2122

In stock

SKU-Size Size Price Qty
B2122-5 5 mg
B2122-25 25 mg
More Sizes Get Quote

Product Details

Alternate Name Propan-2-yl (Z)-3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]prop-2-enoate
Appearance Crystalline solid
CAS # 1333151-73-7
Molecular Formula C₁₆H₁₆F₃N₃O₃
Molecular Weight 355.31
Purity ≥98% by HPLC
Solubility DMSO (>15 mg/ml)
InChi InChI=1S/C16H16F3N3O3/c1-10(2)25-14(23)4-5-22-9-20-15(21-22)11-6-12(16(17,18)19)8-13(7-11)24-3/h4-10H,1-3H3/b5-4-
PubChem CID 53495165
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


KPT-185 is a selective and irreversible inhibitor of chromosome maintenance protein 1 (CRM1). It displays potent antiproliferative properties at submicromolar concentrations (IC₅₀ = 100-500 nM), induces apoptosis (average 5-fold increase), cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.