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Kobe2602

A Ras inhibitor
Catalog #: B1710
SKU-Size Size Price Qty
B1710-5 5 mg
$95.00
B1710-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name Kobe2602; kobe 2602; kobe-2602; Kobe 2602; Kobe-2602; 2-(2,6-dinitro-4-(trifluoromethyl)phenyl)-N-(4-fluorophenyl)hydrazinecarbothioamide; 1-[2,6-dinitro-4-(trifluoromethyl)anilino]-3-(4-fluorophenyl)thiourea
Appearance Solid
CAS # 454453-49-7
Molecular Formula C₁₄H₉F₄N₅O₄S
Molecular Weight 419.31
Purity >98%
Solubility DMSO
SMILES C1=CC(=CC=C1NC(=S)NNC2=C(C=C(C=C2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])F
InChi InChI=1S/C14H9F4N5O4S/c15-8-1-3-9(4-2-8)19-13(28)21-20-12-10(22(24)25)5-7(14(16,17)18)6-11(12)23(26)27/h1-6,20H,(H2,19,21,28)
InChi Key NNPBSITXCGPXJC-UHFFFAOYSA-N
PubChem CID 3827738
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Kobe2602 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD; exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 149 ± 55 μM.


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