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KN-93

A Ca²⁺/calmodulin-dependent kinase type II inhibitor
Catalog #: 2524
SKU-Size Size Price Qty
2524-250 250 µg
$75.00
2524-1000 1 mg
$225.00
More Sizes Get Quote

Product Details

Alternate Name N-​[2-​[[[3-​(4-​chlorophenyl)-​2-​propen-​1-​yl]methylamino]methyl]phenyl]-​N-​(2-​hydroxyethyl)-​4-​methoxy-​benzenesulfonamide
Appearance White solid
CAS # 139298-40-1
Molecular Formula C₂₆H₂₉ClN₂O₄S
Molecular Weight 501.04
Purity ≥98%
Solubility DMSO (>40 mg/ml)
SMILES CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC
InChi InChI=1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+
InChi Key LLLQTDSSHZREGW-AATRIKPKSA-N
PubChem CID 5312122
MDL Number MFCD03788201
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. KN-93 is a potent inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaM kinase II) (IC₅₀ = 0.37 μM). It does not affect the activities of PKA, PKC, MLCK, or Ca2+-phosphodiesterase. Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC₅₀ = 307 nM for Kv1.5). More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes.


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