Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

KN-62

A selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II
Catalog #: 2495
SKU-Size Size Price Qty
2495-1 1 mg
$125.00
2495-5 5 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 4-​[(2S)-​2-​[(5-​isoquinolinylsulfonyl)methylamino]-​3-​oxo-​3-​(4-​phenyl-​1-​piperazinyl)propyl]phenyl ester,​ 5-​isoquinolinesulfonic acid
Appearance Pale yellow solid
CAS # 127191-97-3
Molecular Formula C₃₈H₃₅N₅O₆S₂
Molecular Weight 721.84
Purity ≥98%
Solubility DMSO (>50 mg/ml)
SMILES CN(C(CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7
InChi InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
InChi Key RJVLFQBBRSMWHX-DHUJRADRSA-N
PubChem CID 5312126
MDL Number MFCD00083180
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. KN-62 is a selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaMKII; IC₅₀= 900 nM). It binds directly to the calmodulin binding site of the enzyme. It does not affect the activity of several other kinases when tested at 10 µM. KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC₅₀ = 15 nM).


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.