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A selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II
Catalog #: 2495
SKU-Size Size Price Qty
2495-1 1 mg
2495-5 5 mg
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Product Details

Alternate Name 4-​[(2S)-​2-​[(5-​isoquinolinylsulfonyl)methylamino]-​3-​oxo-​3-​(4-​phenyl-​1-​piperazinyl)propyl]phenyl ester,​ 5-​isoquinolinesulfonic acid
Appearance Pale yellow solid
CAS # 127191-97-3
Molecular Formula C₃₈H₃₅N₅O₆S₂
Molecular Weight 721.84
Purity ≥98%
Solubility DMSO (>50 mg/ml)
InChi InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
PubChem CID 5312126
MDL Number MFCD00083180
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. KN-62 is a selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaMKII; IC₅₀= 900 nM). It binds directly to the calmodulin binding site of the enzyme. It does not affect the activity of several other kinases when tested at 10 µM. KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC₅₀ = 15 nM).

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