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An ATP-competitive allosteric IRE1-α inhibitor
Catalog #: B2594
SKU-Size Size Price Qty
B2594-5 5 mg
B2594-25 25 mg
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Product Details

Alternate Name KIRA 6, KIRA6, 1-(4-(8-Amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea, KIRA-6
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 1589527-65-0
Molecular Formula C₂₈H₂₅F₃N₆O
Molecular Weight 518.54
Purity ≥98% by HPLC
Solubility ~20 mg/ml in DMSO
InChi InChI=1S/C28H25F3N6O/c1-27(2,3)25-36-22(23-24(32)33-13-14-37(23)25)20-11-12-21(19-10-5-4-9-18(19)20)35-26(38) 34-17-8-6-7-16(15-17)28(29,30)31/h4-15H,1-3H3,(H2,32,33)(H2,34,35,38)
PubChem CID 73425700
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


KIRA-6 is an ATP-competitive IRE1α kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1α RNase kinase activity (IC₅₀ = 0.6 µM) and blocks oligomerization. It has been shown to inhibit IRE1α in vivo and to promote cell survival under ER stress.

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