Product Details
| Cat # +Size | 1904-1 |
|---|---|
| Size | 1 mg |
| Alternate Name | 9-Bromo-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one |
| Appearance | Tan solid |
| CAS # | 142273-20-9 |
| Molecular Formula | C₁₆H₁₁BrN₂O |
| Molecular Weight | 327.18 |
| Purity | ≥98% |
| Solubility | DMSO (>25 mg/ml) |
| SMILES | C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br |
| InChi | InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20) |
| InChi Key | QQUXFYAWXPMDOE-UHFFFAOYSA-N |
| PubChem CID | 3820 |
| MDL Number | MFCD02683595 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases. In addition, it has been found to be a useful GSK-3β inhibitor (IC₅₀ = 23nM). More recently, kenpaullone has been shown to increase neurogenesis of human neural progenitor cells through stimulation of Wnt/β-catenin signaling pathway.
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