A potent CDK inhibitor
Catalog #: 1904 | abID:

Product Details

Cat # +Size 1904-1
Size 1 mg
Alternate Name 9-Bromo-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one
Appearance Tan solid
CAS # 142273-20-9
Molecular Formula C₁₆H₁₁BrN₂O
Molecular Weight 327.18
Purity ≥98%
Solubility DMSO (>25 mg/ml)
InChi InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
PubChem CID 3820
MDL Number MFCD02683595
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases. In addition, it has been found to be a useful GSK-3β inhibitor (IC₅₀ = 23nM). More recently, kenpaullone has been shown to increase neurogenesis of human neural progenitor cells through stimulation of Wnt/β-catenin signaling pathway.

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