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KD 5170

A histone deacetylase inhibitor
Catalog #: B2820
SKU-Size Size Price Qty
B2820-1 1 mg
B2820-5 5 mg
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Product Details

Alternate Name S-[2-[6-[[4-[3-(dimethylamino)propoxy]phenyl]sulfonylamino]pyridin-3-yl]-2-oxoethyl] ethanethioate, S-(2-(6-(4-(3-(Dimethylamino)propoxy)phenylsulfonamido)pyridin-3-yl)-2-oxoethyl) ethanethioate
Appearance Crystalline solid
CAS # 940943-37-3
Molecular Formula C₂₀H₂₅N₃O₅S₂
Molecular Weight 451.56
Purity ≥98%
Solubility ~1 mg/ml in DMSO
InChi InChI=1S/C20H25N3O5S2/c1-15(24)29-14-19(25)16-5-10-20(21-13-16)22-30(26,27)18-8-6-17(7-9-18)28-12-4-11-23(2)3/h5-10,13H,4,11-12,14H2,1-3H3,(H,21,22)
PubChem CID 17754557
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


KD 5170 is a broad spectrum, classes I and II HDAC (histone deacetylase) inhibitor. The IC₅₀ for inhibition of HDAC1, HDAC2, HDAC3, HDAC4 is 0.02 μM, 2 μM, 0.075 μM, 0.026 μM respectively, in vitro. KD5170 induced apoptosis in a broad range of human tumor-derived cell lines. It inhibited xenograft tumors in nude mice.

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