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A small molecule HIF-1 pathway inhibitor
Catalog #: 9641
SKU-Size Size Price Qty
9641-10 10 mg
9641-50 50 mg
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Product Details

Alternate Name N,N'-(dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide
Appearance White solid
CAS # 927822-86-4
Molecular Formula C₁₆H₁₆Cl₄N₂O₄S₄
Molecular Weight 570.38
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml)
InChi InChI=1S/C16H16Cl4N2O4S4/c17-11-1-3-13(19)15(9-11)29(23,24)21-5-7-27-28-8-6-22-30(25,26)16-10-12(18)2-4-14(16)20/h1-4,9-10,21-22H,5-8H2
PubChem CID 16047442
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


KC7F2 is a small molecule HIF-1 pathway inhibitor that inhibits HIF-1α protein translation, but not transcription. It inhibits hypoxia-induced expression of several HIF target genes, such as carbonic anhydrase IX, matrix metalloproteinase 2, enolase 1, and endothelin 1. KC7F2 is cytotoxic to a variety of cancer cell lines with an IC₅₀ value of 15-25 µM.

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