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kb NB 142-70

A selective protein kinase D (PKD) inhibitor
Catalog #: 9566
SKU-Size Size Price Qty
9566-5 5 mg
$165.00
9566-25 25 mg
$650.00
More Sizes Get Quote

Product Details

Alternate Name 9-Hydroxy-3,4-dihydro-2H-[1]-benzothiolo[2,3-f][1,4]thiazepin-5-one
Appearance Off-white solid
CAS # 1233533-04-4
Molecular Formula C₁₁H₉NO₂S₂
Molecular Weight 251.32
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
SMILES C1CSC2=C(C(=O)N1)SC3=C2C=C(C=C3)O
InChi InChI=1S/C11H9NO2S2/c13-6-1-2-8-7(5-6)9-10(16-8)11(14)12-3-4-15-9/h1-2,5,13H,3-4H2,(H,12,14)
InChi Key DHUAGGSHTKPOHU-UHFFFAOYSA-N
PubChem CID 45258277
MDL Number MFCD18086915
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

kb NB 142-70 is a selective protein kinase D (PKD) inhibitor with IC₅₀ values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively. More potent analog of CID-755673 (Cat.No. 2660) with 7-fold greater inhibition. Inhibits prostate cancer cell migration and invasion and reduces wound healing in vitro; displays prominent cytotoxic and anti-proliferative effects.


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