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Kaempferol

An antioxidant and apoptosis inducer
Catalog #: 2523
SKU-Size Size Price Qty
2523-50 50 mg
$85.00
2523-250 250 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 3,4′,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, Robigenin
Appearance Yellow solid
CAS # 520-18-3
Molecular Formula C₁₅H₁₀O₆
Molecular Weight 286.24
Purity ≥95% by HPLC
Solubility DMSO (25 mg/ml) or EtOH (20 mg/ml)
SMILES C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O
InChi InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
InChi Key IYRMWMYZSQPJKC-UHFFFAOYSA-N
PubChem CID 5280863
MDL Number MFCD00016938
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A naturally occurring polyphenol antioxidant that displays a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, neuroprotective, antidiabetic, anti-osteoporotic, estrogenic/antiestrogenic, anxiolytic, analgesic and antiallergic activities. It reduces cell cycle progression in HT-29 cells. Kaempferol increases chromatin condensation, DNA fragmentation and the number of early apoptotic cells in HT-29 cells in a dose-dependent manner. In addition, kaempferol increases the levels of cleaved caspase-9, caspase-3 and caspase-7 as well as those of cleaved poly (ADP-ribose) polymerase. Moreover, it increases mitochondrial membrane permeability and cytosolic cytochrome c concentrations.


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