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Type I bone morphogenic protein (BMP) receptors inhibitors
Catalog #: B2321

In stock

SKU-Size Size Price Qty
B2321-5 5 mg
B2321-25 25 mg
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Product Details

Alternate Name 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-phenol
Appearance Off-white solid
CAS # 1431985-92-0
Molecular Formula C₂₀H₂₀N₂O₄
Molecular Weight 352.38
Purity ≥98% by HPLC
Solubility >30 mg/ml in DMSO
InChi InChI=1S/C20H20N2O4/c1-24-17-9-13(10-18(25-2)19(17)26-3)16-8-14(11-22-20(16)21)12-5-4-6-15(23)7-12/h4-11,23H,1-3H3,(H2,21,22)
PubChem CID 46173038
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC₅₀ values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC₅₀ = 100 nM) without affecting TGF-β signaling.

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