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JZL195

A potent dual inhibitor of Monoacylglycerol lipase (MAGL)
Catalog #: B1064
SKU-Size Size Price Qty
B1064-5 5 mg
$85.00
B1064-25 25 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 4-[(3-Phenoxyphenyl)methyl]-1-piper​azinecarboxylic acid 4-nitrophenyl ester
Appearance White to off-white solid
CAS # 1210004-12-8
Molecular Formula C₂₄H₂₃N₃O₅
Molecular Weight 433.46
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
SMILES C1CN(CCN1CC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)OC4=CC=C(C=C4)[N+](=O)[O-]
InChi InChI=1S/C24H23N3O5/c28-24(32-22-11-9-20(10-12-22)27(29)30)26-15-13-25(14-16-26)18-19-5-4-8-23(17-19)31-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2
InChi Key QNYRAEKLMNDRFY-UHFFFAOYSA-N
PubChem CID 46232606
MDL Number MFCD18382122
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) (IC₅₀ = 2 nM) and fatty acid amide hydrolase (FAAH) (IC₅₀ = 4 nM), enzymes that degrade the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), the endogenous ligands for the cannabinoid G-protein coupled receptors CB1 and CB2. It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation.


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