Product Details
| Alternate Name | N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide |
|---|---|
| Appearance | Off-white solid |
| CAS # | 664993-53-7 |
| Molecular Formula | C₂₅H₂₆N₂O₅ |
| Molecular Weight | 434.48 |
| Purity | >98% by HPLC |
| Solubility | DMSO(~ 40 mg/ml) or EtOH (~ 40 mg/ml) |
| SMILES | O=C(NC1=CC=C(C(NCC2(C3=CC=C(OC)C=C3)CCOCC2)=O)C=C1)C4=CC=CO4 |
| InChi | InChI=1S/C25H26N2O5/c1-30-21-10-6-19(7-11-21)25(12-15-31-16-13-25)17-26-23(28)18-4-8-20(9-5-18)27-24(29)22-3-2-14-32-22/h2-11,14H,12-13,15-17H2,1H3,(H,26,28)(H,27,29) |
| InChi Key | ZJZWZIXSGNFWQQ-UHFFFAOYSA-N |
| PubChem CID | 2946601 |
| Handling | Protect from air and light |
| Storage Conditions | -20 ̊C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
JW55 is a small molecule inhibitor of the Wnt/β-catenin signaling pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2), regulators of the β-catenin destruction complex. Inhibition of TNKS1/2 poly(ADP-ribosyl)ation activity by JW55 leads to stabilization of AXIN2, a member of the β-catenin destruction complex, followed by increased degradation of β-catenin. In a dose-dependent manner, JW55 inhibits canonical Wnt signaling in colon carcinoma cells that contained mutations in either the APC (adenomatous polyposis coli) locus or in an allele of β-catenin.
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