Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

JW55

A Wnt/β-catenin signaling pathway inhibitor
Catalog #: 2612

In stock

SKU-Size Size Price Qty
2612-5 5 mg
$80.00
2612-25 25 mg
$320.00
More Sizes Get Quote

Product Details

Alternate Name N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
Appearance Off-white solid
CAS # 664993-53-7
Molecular Formula C₂₅H₂₆N₂O₅
Molecular Weight 434.48
Purity >98% by HPLC
Solubility DMSO(~ 40 mg/ml) or EtOH (~ 40 mg/ml)
SMILES O=C(NC1=CC=C(C(NCC2(C3=CC=C(OC)C=C3)CCOCC2)=O)C=C1)C4=CC=CO4
InChi InChI=1S/C25H26N2O5/c1-30-21-10-6-19(7-11-21)25(12-15-31-16-13-25)17-26-23(28)18-4-8-20(9-5-18)27-24(29)22-3-2-14-32-22/h2-11,14H,12-13,15-17H2,1H3,(H,26,28)(H,27,29)
InChi Key ZJZWZIXSGNFWQQ-UHFFFAOYSA-N
PubChem CID 2946601
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

JW55 is a small molecule inhibitor of the Wnt/β-catenin signaling pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2), regulators of the β-catenin destruction complex. Inhibition of TNKS1/2 poly(ADP-ribosyl)ation activity by JW55 leads to stabilization of AXIN2, a member of the β-catenin destruction complex, followed by increased degradation of β-catenin. In a dose-dependent manner, JW55 inhibits canonical Wnt signaling in colon carcinoma cells that contained mutations in either the APC (adenomatous polyposis coli) locus or in an allele of β-catenin.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.