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Jumonji HDM Inhibitor, PBIT

A potent jumonji HDM inhibitor
Catalog #: 2475
SKU-Size Size Price Qty
2475-5 5 mg
$145.00
2475-25 25 mg
$550.00
More Sizes Get Quote

Product Details

Alternate Name 2-4(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one
Appearance White solid
CAS # 2514-30-9
Molecular Formula C₁₄H₁₁NOS
Molecular Weight 241.31
Purity ≥98% by HPLC
Solubility DMSO (~50 mg/ml)
SMILES CC1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3S2
InChi InChI=1S/C14H11NOS/c1-10-6-8-11(9-7-10)15-14(16)12-4-2-3-5-13(12)17-15/h2-9H,1H3
InChi Key KRXMYBAZKJBJAB-UHFFFAOYSA-N
PubChem CID 935415
MDL Number MFCD05856231
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PBIT is a potent, cell-permeable inhibitor of Jumonji histone demethylase (JHDM). Innhibits JARID1B (also known as KDM5B or PLU1) with an IC₅₀ of about 3 μm in vitro. PBIT treatment inhibits removal of H3K4me3 by JARID1B in cells and inhibits proliferation of cells expressing higher levels of JARID1B.


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