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Jumonji HDM Inhibitor, JIB-04

A potent jumonji HDM inhibitor
Catalog #: 2474
SKU-Size Size Price Qty
2474-5 5 mg
$95.00
2474-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name 5-Chloro-2-[(E)-2-[phenyl(pyridin-2​-yl)methylidene]hydrazin-1-yl]pyridine; NSC693627
Appearance White solid
CAS # 199596-05-9
Molecular Formula C₁₇H₁₃ClN₄
Molecular Weight 308.76
Purity ≥98% by HPLC
Solubility DMSO (~20 mg/ml)
SMILES C1=CC=C(C=C1)C(=NNC2=NC=C(C=C2)Cl)C3=CC=CC=N3
InChi InChI=1S/C17H13ClN4/c18-14-9-10-16(20-12-14)21-22-17(13-6-2-1-3-7-13)15-8-4-5-11-19-15/h1-12H,(H,20,21)/b22-17+
InChi Key YHHFKWKMXWRVTJ-OQKWZONESA-N
PubChem CID 6519698
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

JIB-04 (E-isomer) is a potent, cell-permeable inhibitor of Jumonji histone demethylases in vitro and in vivo. (In vitro IC₅₀ values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). JIB-04 is not a competitive inhibitor of α-ketoglutarate ; it selectively inhibits viability of several human cancer cell lines with little toxicity towards normal cells, and also diminishes tumor growth in xenograft mouse models.


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