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JTE-607 dihydrochloride

A multiple cytokine inhibitor
Catalog #: B3064
SKU-Size Size Price Qty
B3064-5 5 mg
B3064-25 25 mg
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Product Details

Alternate Name ethyl (2S)-2-[[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]amino]-3-phenylpropanoate;dihydrochloride; L-Phenylalanine, N-(3,5-dichloro-2-hydroxy-4-(2-(4-methyl-1-piperazinyl)ethoxy)benzoyl)-, ethyl ester, dihydrochloride
Appearance Off White solid
CAS # 188791-09-5
Molecular Formula C₂₅H₃₃Cl₄N₃O₅
Molecular Weight 597.36
Purity ≥98%
Solubility ~25 mg/ml in DMSO
InChi InChI=1S/C25H31Cl2N3O5.2ClH/c1-3-34-25(33)20(15-17-7-5-4-6-8-17)28-24(32)18-16-19(26)23(21(27)22(18)31)35-14-13-30-11-9-29(2)10-12-30;;/h4-8,16,20,31H,3,9-15H2,1-2H3,(H,28,32);2*1H/t20-;;/m0../s1
PubChem CID 9938544
MDL Number MFCD07363998
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


JTE-607 is a multiple cytokine inhibitor. It inhibits cytokine production specifically in human peripheral blood mononuclear cells without causing immunosuppression. It inhibits tumor necrosis factor-α (TNF-α), interleukins IL-1β, IL-6, IL-8 and IL-10 from LPS-stimulated human PBMCs with IC₅₀ values of 11 nM, 5.9 nM, 8.8 nM, 7.3 nM and 9.1 nM, respectively. It (0.4-0.8 μM) also inhibits the growth of acute myelogenous leukemia cell lines by inducing apoptosis and cell-cycle arrest.

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