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(-)-JQ1

A negative control for (+)-JQ1 (Cat. No. 2070).
Catalog #: 2384
$125.00

Product Details

Cat # +Size 2384-1
Size 1 mg
Alternate Name t-Butyl-2-((6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Appearance Off-white solid
CAS # 1268524-71-5
Molecular Formula C₂₃H₂₅ClN₄O₂S
Molecular Weight 456.99
Purity ≥98% by HPLC
Solubility DMSO (~10 mg/ml)
SMILES CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
InChi InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m1/s1
InChi Key DNVXATUJJDPFDM-QGZVFWFLSA-N
PubChem CID 49871818
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A useful negative control for the BET bromodomain inhibitor (+)-JQ1 (Cat.No.2070). (−)-JQ1 enantiomer has no appreciable affinity to BET bromodomains, whereas enantiomerically pure (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively.


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