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JNK-IN-7

A selective JNK inhibitor
Catalog #: B1695
SKU-Size Size Price Qty
B1695-1 1 mg
$125.00
B1695-5 5 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name JNK-IN-7; JNK-IN7; JNKIN-7; JNKIN7; JNK IN 7; 3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]-N-[4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Appearance Solid
CAS # 1408064-71-0
Molecular Formula C₂₈H₂₇N₇O₂
Molecular Weight 493.56
Purity >98%
Solubility DMSO
SMILES CN(C)CC=CC(=O)NC1=CC=CC(=C1)C(=O)NC2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CN=CC=C4
InChi InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-24-8-3-6-20(18-24)27(37)32-22-10-12-23(13-11-22)33-28-30-16-14-25(34-28)21-7-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+
InChi Key RADRIIWGHYFWPP-WEVVVXLNSA-N
MDL Number 57340685
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

JNK-IN-7 is a selective JNK inhibitor with IC50 values of 1.54 nM, 1.99 nM, 0.75 nM to JNK1, JNK2, JNK3, respectively. It also inhibits phosphorylation of c-Jun, which is a direct substrate of JNK kinase.


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