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JNJ-47965567

A selective P2X7 antagonist
Catalog #: B2972
SKU-Size Size Price Qty
B2972-5 5 mg
$125.00
B2972-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name N-[[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl]-2-phenylsulfanylpyridine-3-carboxamide; N-((4-(4-phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide; 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl]-3-pyridinecarboxamide; P2X Antagonist III
Appearance Solid
CAS # 1428327-31-4
Molecular Formula C₂₈H₃₂N₄O₂S
Molecular Weight 488.64
Purity 98%
Solubility ~12.5 mg/ml in Ethanol, ~30 mg/ml in DMSO and DMF
SMILES C1COCCC1(CNC(=O)C2=C(N=CC=C2)SC3=CC=CC=C3)N4CCN(CC4)C5=CC=CC=C5
InChi InChI=1S/C28H32N4O2S/c33-26(25-12-7-15-29-27(25)35-24-10-5-2-6-11-24)30-22-28(13-20-34-21-14-28)32-18-16-31(17-19-32)23-8-3-1-4-9-23/h1-12,15H,13-14,16-22H2,(H,30,33)
InChi Key XREFXUCWSYMIOG-UHFFFAOYSA-N
PubChem CID 66553218
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

JNJ-47965567 is a potent and selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel. Activation of P2X receptors by BzATP induces calcium flux. JNJ-47965567 attenuates Bz-ATP induced calcium flux in 1321N1 astrocytoma cells transfected with the recombinant P2X7 proteins with pIC₅₀ values of 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively. JNJ-47965567 (30 mg/kg for 5 days) significantly reduces spontaneous seizures in epileptic mice even after treatment is stopped.


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