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A potent and selective HIF-PHD inhibitor
Catalog #: B1072
SKU-Size Size Price Qty
B1072-5 5 mg
B1072-25 25 mg
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Product Details

Alternate Name 1-[6-chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl]-1H-pyrazole-4-carboxylic acid
Appearance White to off-white solid
CAS # 1193383-09-3
Molecular Formula C₁₂H₆ClF₃N₄O₃
Molecular Weight 346.65
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml)
SMILES C1=C2C(=CC(=C1Cl)OC(F)(F)F)N=C(N2)N3C=C(C=N3)C(=O)O
InChi 1S/C12H6ClF3N4O3/c13-6-1-7-8(2-9(6)23-12(14,15)16)19-11(18-7)20-4-5(3-17-20)10(21)22/h1-4H,(H,18,19)(H,21,22)
PubChem CID 45102710
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


JNJ-42041935 is a HIF-PHD (Hypoxia-inducible factor- prolyl hydroxylase) inhibitor. JNJ-42041935 is a selective, 2-OG (2-oxoglutarate) competitive, and reversible inhibitor of PHD enzymes (pKis = 7.91, 7.29, and 7.65 for PHD1, 2, and 3, respectively). It is >100-fold selective for PHD compared to the related FIH (factor-inhibiting HIF) and a panel of various other enzymes.

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