Product Details
| Alternate Name | 6-(difluoro(6-(1-methyl-1H-pyrazol-3-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 943540-75-8 |
| Molecular Formula | C₁₉H₁₃F₂N₇ |
| Molecular Weight | 377.35 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO |
| SMILES | CN1C=C(C=N1)C2=NN3C(=NN=C3C(C4=CC5=C(C=C4)N=CC=C5)(F)F)C=C2 |
| InChi | InChI=1S/C19H13F2N7/c1-27-11-13(10-23-27)16-6-7-17-24-25-18(28(17)26-16)19(20,21)14-4-5-15-12(9-14)3-2-8-22-15/h2-11H,1H3 |
| InChi Key | JRWCBEOAFGHNNU-UHFFFAOYSA-N |
| PubChem CID | 46911863 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
JNJ-38877605 is a potent c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (IC₅₀ values of 4 nM and 50 nM for c-MET enzyme and Phospho-MET respectively). Displays selectivity over 229 other kinases tested.
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