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A novel HDM2 (Human Double Minute-2) antagonist
Catalog #: 2479
SKU-Size Size Price Qty
2479-5 5 mg
2479-25 25 mg
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Product Details

Alternate Name 1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine; Serdemetan
Appearance Off-white solid
CAS # 881202-45-5
Molecular Formula C₂₁H₂₀N₄
Molecular Weight 328.41
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml)
InChi InChI=1S/C21H20N4/c1-2-4-21-20(3-1)16(15-24-21)9-14-23-17-5-7-18(8-6-17)25-19-10-12-22-13-11-19/h1-8,10-13,15,23-24H,9,14H2,(H,22,25)
PubChem CID 11609586
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A novel p53-activating tryptamine derivative that acts as a HDM2 (Human Double Minute-2) antagonist with potential antineoplastic activity. JNJ-26854165 inhibits the binding of the HDM2–p53 complex to the proteasome, blocking the degradation of p53. It displays potent anti-proliferative and apoptosis-inducing activity in a broad range of p53 wild type and mutant tumor models.

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