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JMJD6 Antibody

Polyclonal antibody to detect JMJD6 (a lysine specific demethylase) in human Chimpanzee, Bovine, Canine, Equine, Mouse and Opossum samples
Catalog #: 6109
$225.00

Product Details

Cat # +Size 6109-50
Size 50 μg
Antibody Target JMJD6
Alternate Name Jumonji Domain Containing 6; PTDSR
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Human recombinant JMJD2A aa 127-144
Accession # Q6NYC1
Gene ID 23210
Appearance Colorless liquid
Formulation 50 µg of antibody in 100 µl PBS containing 0.05% BSA and 0.05% sodium salt.
Purification Antigen affinity purified
Species Reactivity Human, chimpanzee, bovine, canine, equine, mouse, opossum
Application Western blot
Positive Control Western blot: Human brain lysate, mouse brain lysate
Application & Usage Western blot: 0.25-1.0 µg/ml. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tudor domains are small protein structural motifs of about ~50 amino acids related to the “royal family” of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification, and chromatin remodeling. The tudor domains recognize symmetric methylated arginine or methylated lysine residues. JMJD6 is a 403 amino acid nuclear protein lysyl-hydroxylase that has been reported to have arginine demethylase activity for histone H3 at ‘Arg-2’ and histone H4 at ‘Arg-3’. JMJD6 has been sμggested to function in the differentiation of multiple organs during embryogenesis and regulate hematopoietic differentiation and macrophage cytokine responses. First identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells, JMJD6 was later indicated not to directly function in the clearance of apoptotic cells. It is ubiquitously expressed in most tissues and is upregulated in patients with chronic pancreatitis and upon cytokine treatment, but not upon TNF-α treatment.


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