A small molecule inhibitor of SIRT1
Catalog #: B2804 | abID:

Product Details

Alternate Name 4,5,6,7-tetrahydro-2-[(E)-[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(phenylmethyl)-benzo[b]thiophene-3-carboxamide
Appearance Crystalline solid
CAS # 1256375-38-8
Molecular Formula C₂₇H₂₄N₂O₂S
Molecular Weight 440.56
Purity ≥98%
Solubility 0.2 mg/ml in in DMSO, ~0.14 mg/ml in DMF
InChi InChI=1S/C27H24N2O2S/c30-23-15-14-19-10-4-5-11-20(19)22(23)17-29-27-25(21-12-6-7-13-24(21)32-27)26(31)28-16-18-8-2-1-3-9-18/h1-5,8-11,14-15,17,30H,6-7,12-13,16H2,(H,28,31)/b29-17+
PubChem CID 136232142
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


JGB1741 is a small molecule inhibitor of SIRT1. The sirtuins (SIRTs) are NAD+-dependent histone deacetylases. The IC₅₀ value of JGB1741 in a cell-free assay is 15 μM. The IC₅₀ for cell proliferation of three cancer cell lines, K562, HepG2 and MDA-MB 231 is 1 μM, 10 μM and 0.5 μM, respectively. JGB1741 causes cytochrome c release, modulation in Bax/Bcl2 ratio and cleavage of PARP.

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