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An inhibitor of SIRT2
Catalog #: B2830
SKU-Size Size Price Qty
B2830-1 1 mg
B2830-5 5 mg
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Product Details

Alternate Name 1,4-bis[2-(4-hydroxyphenyl)ethylamino]anthracene-9,10-dione; 1,4-bis[2-(p-hydroxyphenyl)ethylamino]anthraquinone; BML-266
Appearance Crystalline solid
CAS # 96969-83-4
Molecular Formula C₃₀H₂₆N₂O₄
Molecular Weight 478.54
Purity ≥95%
Solubility ~0.3 mg/ml in Ethanol
~30 mg/ml in DMSO and DMF
InChi InChI=1S/C30H26N2O4/c33-21-9-5-19(6-10-21)15-17-31-25-13-14-26(32-18-16-20-7-11-22(34)12-8-20)28-27(25)29(35)23-3-1-2-4-24(23)30(28)36/h1-14,31-34H,15-18H2
PubChem CID 2817242
MDL Number MFCD00208443
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


JFD00244 is an inhibitor of SIRT2. SIRT2 is a NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. A major substrate of SIRT2 is α-tubulin. JFD00244 inhibits SIRT2 with an IC₅₀ of 56.7 µM. It induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4 at a concentration of 5 μM.

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