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A sonic hedgehog (Shh) pathway inhibitor
Catalog #: 2357
SKU-Size Size Price Qty
2357-1 1 mg
2357-5 5 mg
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Product Details

Alternate Name (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,1­1bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexad­ecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H­-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1­H)-one
Appearance White to off-white solid
CAS # 469-59-0
Molecular Formula C₂₇H₃₉NO₃
Molecular Weight 425.6
Purity ≥98% by TLC
Solubility DMSO (5 mg/ml) or EtOH (10 mg/ml)
InChi InChI=1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1
PubChem CID 10098
MDL Number MFCD01684066
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. Structurally similar to cyclopamine (Cat. No. 1578). Inhibits the sonic hedgehog (shh) pathway by interacting with smoothened. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Tomatidine (Cat. No. 1893) is a useful negative control.

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