Product Details
| Cat # +Size | 1130-5 |
|---|---|
| Size | 5 mg |
| Alternate Name | 5,5’,6,6’-tetrachloro-1,1’,3,3’-tetraethyl-benzimidazolylcarbocyanine Iodide |
| Appearance | Brown red solid |
| CAS # | 3520-43-2 |
| Molecular Formula | C₂₅H₂₇Cl₄IN₄ |
| Molecular Weight | 652.23 |
| Purity | >98% by HPLC |
| Solubility | DMSO and DMF |
| SMILES | CCN1C2=CC(=C(C=C2[N+](=C1C=CC=C3N(C4=CC(=C(C=C4N3CC)Cl)Cl)CC)CC)Cl)Cl.[I-] |
| InChi | InChI=1S/C25H27Cl4N4.HI/c1-5-30-20-12-16(26)17(27)13-21(20)31(6-2)24(30)10-9-11-25-32(7-3)22-14-18(28)19(29)15-23(22)33(25)8-4;/h9-15H,5-8H2,1-4H3;1H/q+1;/p-1 |
| InChi Key | FYNNIUVBDKICAX-UHFFFAOYSA-M |
| PubChem CID | 5492929 |
| MDL Number | MFCD00188475 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
JC-1 is a mitochondrial dye that stains mitochondria in Living cells in a membrane potential-dependent fashion. JC-1 monomer is in equilibrium with so called J-aggregates, which are favored at higher mitochondrial membrane potential. The monomer JC-1 has green fluorescence (lem = 527 nm), while the J-aggregates have red fluorescence (lem = 590 nm). Therefore, it has been possible to use fluorescence ratioing technique to study mitochondrial membrane potential. JC-1 is particularly useful for apoptosis studies. In apoptotic cells, the dye stays in the cytoplasm and fluoresces green, while in healthy cells, the dye aggregates in the mitochondria and fluoresces red.
Why buy BioVision Products?
 |
 |
 |
 |
Innovation |
Affordability |
Global Presence |
Technical Support |
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways. |
BioVision is committed to providing the highest quality products at a competitive price. |
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery. |
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently. |
Yi-Huan Chen, MEHP interferes with mitochondrial functions and homeostasis in skeletal muscle cells. Biosci Rep., Apr. 2020; 32255176.
Hai-Yan Hou, Evidence that growth hormone can improve mitochondrial function in oocytes from aged mice. Reproduction., Jan. 2019; 30668522
Hung et al., Docetaxel Facilitates Endothelial Dysfunction through Oxidative Stress via Modulation of Protein Kinase C Beta: The Protective Effects of Sotrastaurin. Toxicol. Sci., May 2015; 145: 59 - 67.
Trondl et al., Triapine and a More Potent Dimethyl Derivative Induce Endoplasmic Reticulum Stress in Cancer Cells. Mol. Pharmacol., Jan 2014; 85: 451 - 459.
Ling-Yi Chen et al., Taiwanofungus camphoratus (Syn Antrodia camphorata) Extract and Amphotericin B Exert Adjuvant Effects via Mitochondrial Apoptotic Pathway. Integr Cancer Ther, Mar 2013; 12: 153 - 164.
For more citations of this product click here
