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JC-1

based on 6 citations in multiple journalsJC-164.1 4
A mitochondrial dye
Catalog #: 1130
$275.00

Product Details

Cat # +Size 1130-5
Size 5 mg
Alternate Name 5,5’,6,6’-tetrachloro-1,1’,3,3’-tetraethyl-benzimidazolylcarbocyanine Iodide
Appearance Brown red solid
CAS # 3520-43-2
Molecular Formula C₂₅H₂₇Cl₄IN₄
Molecular Weight 652.23
Purity >98% by HPLC
Solubility DMSO and DMF
SMILES CCN1C2=CC(=C(C=C2[N+](=C1C=CC=C3N(C4=CC(=C(C=C4N3CC)Cl)Cl)CC)CC)Cl)Cl.[I-]
InChi InChI=1S/C25H27Cl4N4.HI/c1-5-30-20-12-16(26)17(27)13-21(20)31(6-2)24(30)10-9-11-25-32(7-3)22-14-18(28)19(29)15-23(22)33(25)8-4;/h9-15H,5-8H2,1-4H3;1H/q+1;/p-1
InChi Key FYNNIUVBDKICAX-UHFFFAOYSA-M
PubChem CID 5492929
MDL Number MFCD00188475
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

JC-1 is a mitochondrial dye that stains mitochondria in Living cells in a membrane potential-dependent fashion. JC-1 monomer is in equilibrium with so called J-aggregates, which are favored at higher mitochondrial membrane potential. The monomer JC-1 has green fluorescence (lem = 527 nm), while the J-aggregates have red fluorescence (lem = 590 nm). Therefore, it has been possible to use fluorescence ratioing technique to study mitochondrial membrane potential. JC-1 is particularly useful for apoptosis studies. In apoptotic cells, the dye stays in the cytoplasm and fluoresces green, while in healthy cells, the dye aggregates in the mitochondria and fluoresces red.


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Yi-Huan Chen, MEHP interferes with mitochondrial functions and homeostasis in skeletal muscle cells. Biosci Rep., Apr. 2020;  32255176.
Hai-Yan Hou, Evidence that growth hormone can improve mitochondrial function in oocytes from aged mice. Reproduction., Jan. 2019;  30668522
Hung et al., Docetaxel Facilitates Endothelial Dysfunction through Oxidative Stress via Modulation of Protein Kinase C Beta: The Protective Effects of Sotrastaurin. Toxicol. Sci., May 2015; 145: 59 - 67.
Trondl et al., Triapine and a More Potent Dimethyl Derivative Induce Endoplasmic Reticulum Stress in Cancer Cells. Mol. Pharmacol., Jan 2014; 85: 451 - 459.
Ling-Yi Chen et al., Taiwanofungus camphoratus (Syn Antrodia camphorata) Extract and Amphotericin B Exert Adjuvant Effects via Mitochondrial Apoptotic Pathway. Integr Cancer Ther, Mar 2013; 12: 153 - 164.
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