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Jarid1c polyclonal antibody

Polyclonal Antibody to detect Jarid 1c in human and mouse samples.
Catalog #: 6855
$185.00

Product Details

Cat # +Size 6855-50
Size 50 μl
Antibody Target Jarid1c
Alternate Name KDM5C, MRXJ, MRXSJ, SMCX, XE169
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Polyclonal antibody raised in rabbit against mouse Jarid1c (jumonji, AT rich interactive domain 1C), using 3 KLH-conjugated synthetic peptides containing sequences from the inner part of the protein.
Accession # P41229
Gene ID 8242
Appearance Colorless liquid
Formulation In PBS with 0.05% (W/V) sodium azide.
Purification Whole Anti-Sera
Species Reactivity Human, mouse.
Application Western blot, ELISA.
Positive Control Western blot: HeLa cells, ELISA: Peptides.
Application & Usage Western Blot: 1:1000, ELISA: 1:500.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Jarid1c is a histone demethylase which specifically demethylates lysine 4 of histone H3, thereby playing a central role in the regulation of transcription and chromatin remodelling. Jarid1c demethylates the trimethylated and dimethylated lysine 4, but not the monomethylated form. Further, Jarid1c participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Mutations in the Jarid1c gene have been associated with X-linked mental retardation.


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