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JAK Inhibitor, Pyridone 6

A potent JAK inhibitor
Catalog #: 2534
SKU-Size Size Price Qty
2534-500 500 µg
$115.00
2534-1000 1 mg
$205.00
More Sizes Get Quote

Product Details

Alternate Name 2-​(1,​1-​Dimethylethyl)-​9-​fluoro-​1,​6-​dihydro-​7H-​benz[h]imidazo[4,​5-​f]isoquinolin-​7-​one; Pyridone 6; CMP 6
Appearance Off-white solid
CAS # 457081-03-7
Molecular Formula C₁₈H₁₆FN₃O
Molecular Weight 309.3
Purity ≥97% by HPLC
Solubility DMSO (5 mg/ml)
SMILES CC(C)(C)C1=NC2=C(N1)C3=C(C=C(C=C3)F)C4=C2C=CNC4=O
InChi InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
InChi Key VNDWQCSOSCCWIP-UHFFFAOYSA-N
PubChem CID 5494425
MDL Number MFCD17019334
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. JAK Inhibitor, Pyridone 6 is a potent, reversible, ATP-competitive JAK inhibitor. It inhibits JAK1, 2, and 3 with IC₅₀ values of 15, 1, and 5 nM, respectively. Displays significantly weaker affinities (IC₅₀s = 130 nM - > 10 μM) for other protein tyrosine kinases. It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC₅₀ values of 50-100 nM.


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