Product Details
| Alternate Name | (R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid, MLN2238, MLN-2238 |
|---|---|
| Appearance | White solid |
| CAS # | 1072833-77-2 |
| Molecular Formula | C₁₄H₁₉BCl₂N₂O₄ |
| Molecular Weight | 361.03 |
| Purity | ≥98% by HPLC |
| Solubility | >25 mg/ml in DMSO |
| SMILES | B(C(CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O |
| InChi | InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1 |
| InChi Key | MXAYKZJJDUDWDS-LBPRGKRZSA-N |
| PubChem CID | 25183872 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Ixazomib (MLN-2238), is a potent proteasome inhibitor (PI) with potential antineoplastic activity. MNL-2238 is a biologically active form of MLN9708. MLN-2238 has an improved pharmacodynamic profile and antitumor activity compared with bortezomib in both OCI-Ly10 and PHTX22L models.
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