A Wnt pathway antagonist
Catalog #: 2650 | abID:

Product Details

Alternate Name N-​(6-​methyl-​2-​benzothiazolyl)-​2-​[[3,​4,​6,​7-​tetrahydro-​3-​(2-​methoxyphenyl)-​4-​oxothieno[3,​2-​d]pyrimidin-​2-​yl]thio]-​acetamide
Appearance Crystaline solid
CAS # 686772-17-8
Molecular Formula C₂₃H₂₀N₄O₃S₃
Molecular Weight 496.62
Purity ≥95% by HPLC
Solubility DMSO (~2 mg/ml)
InChi InChI=1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28)
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


IWP-4 is a potent inhibitor of Wnt production that blocks Wnt pathway activity in vitro (IC₅₀ = 25 nM). IWP-4 inactivates Porcupine (porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 μM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin. IWP-4 has been used to induce cardiomyocyte differentiation from human pluripotent stem cells.

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