An inhibitor of Wnt production
Catalog #: 2349 | abID:

Product Details

Alternate Name Inhibitor of Wnt Production-3; 2-​[[3-​(4-​fluorophenyl)-​3,​4,​6,​7-​tetrahydro-​4-​oxothieno[3,​2-​ d]pyrimidin-​2-​yl]thio]-​N-​(6-​methyl-​2-​benzothiazolyl)-​acetamide
Appearance White to Off-white Solid
CAS # 687561-60-0
Molecular Formula C₂₂H₁₇FN₄O₂S₃
Molecular Weight 484.59
Purity ≥98%
Solubility DMSO (~2 mg/ml on warming)
InChi InChI=1S/C22H17FN4O2S3/c1-12-2-7-15-17(10-12)32-21(24-15)26-18(28)11-31-22-25-16-8-9-30-19(16)20(29)27(22)14-5-3-13(23)4-6-14/h2-7,10H,8-9,11H2,1H3,(H,24,26,28)
MDL Number MFCD04457889
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


An inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).

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