An inhibitor of Wnt secretion and processing
Catalog #: 1962 | abID:

Product Details

Alternate Name N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Appearance Beige solid
CAS # 686770-61-6
Molecular Formula C₂₂H₁₈N₄O₃S₃
Molecular Weight 466.6
Purity ≥98% by TLC
Solubility DMSO (~5 mg/ml with warming)
InChi InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
PubChem CID 2155128
MDL Number MFCD04457599
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. Acts as an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC₅₀ = 27 nM) by inhibition of the O-acyltransferase Porcn. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion.

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