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IVD, Human Recombinant

Flavoenzyme which catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA
Catalog #: P1577
SKU-Size Size Price Qty
P1577-20 20 μg
$105.00
P1577-100 100 μg
$455.00
More Sizes Get Quote

Product Details

Alternate Name Isovaleryl-CoA dehydrogenase mitochondrial, ACAD2
Gene Symbol IVD
Gene ID 3712
Accession # P26440
Source E. coli
Appearance Liquid
Physical Form Description In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 10% glycerol
Molecular Weight 45.3 kDa (415aa) (N-terminal His- Tag)
Purity by SDS-PAGE >90%
Amino Acid Sequence aa 33-426
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

IVD (Isovaleryl Coenzyme A dehydrogenase) is a mitochondrial matrix enzyme that belongs to the acyl-CoA dehydrogenase family. IVD is a homotetrameric flavoenzyme which catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA. Defects of the IVD gene lead to ineffective isoforms that are the underlying cause of isovaleric acidemia. Recombinant human IVD protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.


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