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Ivachtin

A caspase-3 inhibitor
Catalog #: 2788
SKU-Size Size Price Qty
2788-1 1 mg
$125.00
2788-5 5 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
Appearance Tan solid
CAS # 745046-84-8
Molecular Formula C₂₀H₂₁N₃O₇S
Molecular Weight 447.46
Purity ≥98% by HPLC
Solubility DMSO (>4 mg/ml)
SMILES CC1=C2C(=C3C=C(C=CC3=N1)S(=O)(=O)N4CCOCC4)C(=O)N(C2=O)CCOC(=O)C
InChi InChI=1S/C20H21N3O7S/c1-12-17-18(20(26)23(19(17)25)7-10-30-13(2)24)15-11-14(3-4-16(15)21-12)31(27,28)22-5-8-29-9-6-22/h3-4,11H,5-10H2,1-2H3
InChi Key MWXJJTMEUGWKKY-UHFFFAOYSA-N
PubChem CID 11201705
MDL Number MFCD09971108
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Ivachtin is a potent, reversible and non-competitive inhibitor of caspase-3 (IC₅₀ = 23 nM) that displays 10-100 fold selectivity over other caspases. Exhibits antiapoptotic activity in human Jurkat T cells treated with staurosporine; exhibits a higher level of protection than Z-VAD-FMK (Cat. Nos. 1010 and 1140).


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