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ITSA-1

A suppressor of Trichostatin A (TSA)
Catalog #: 2089
SKU-Size Size Price Qty
2089-5 5 mg
$70.00
2089-25 25 mg
$235.00
More Sizes Get Quote

Product Details

Alternate Name N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide, ITSA1
Appearance White solid
CAS # 200626-61-5
Molecular Formula C₁₃H₇Cl₂N₃O
Molecular Weight 292.12
Purity ≥98% by TLC
Solubility DMSO (25 mg/ml)
SMILES C1=CC=C2C(=C1)N=NN2C(=O)C3=C(C=C(C=C3)Cl)Cl
InChi InChI=1S/C13H7Cl2N3O/c14-8-5-6-9(10(15)7-8)13(19)18-12-4-2-1-3-11(12)16-17-18/h1-7H
InChi Key UVNLAUGZMOPBPR-UHFFFAOYSA-N
PubChem CID 771910
MDL Number MFCD00195103
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct acetylation events (histone and tubulin). ITSA-1 specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 reverses TSA induced histone acetylation, overall deacetylation. ITSA-1 also reverses TSA induced cell cycle arrest and apoptosis.


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