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ITF2357

A pan-HDAC inhibitor
Catalog #: 9431
SKU-Size Size Price Qty
9431-1 1 mg
$65.00
9431-5 5 mg
$255.00
More Sizes Get Quote

Product Details

Alternate Name [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate hydrochloride, monohydrate; Givinostat
Appearance Crystalline solid
CAS # 732302-99-7
Molecular Formula C₂₄H₂₇N₃O₄.HCl.H₂O
Molecular Weight 475.97
Purity ≥98% by HPLC
Solubility DMSO (~30 mg/ml)
SMILES CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.O.Cl
InChi InChI=1S/C24H27N3O4.ClH.H2O/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30;;/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28);1H;1H2
InChi Key FKGKZBBDJSKCIS-UHFFFAOYSA-N
PubChem CID 9804991
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ITF2357 is an orally active, hydroxamic-containing pan-histone deacetylase (HDAC) inhibitor with broad anti-inflammatory properties. ITF2357 inhibits both Class I and II HDACs and reduces caspase-1 activity in human peripheral blood mononuclear cells and the secretion of IL-1β and other cytokines at 25-100 nM.


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