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An endogenous aryl hydrocarbon receptor (AhR) agonist
Catalog #: B1579
SKU-Size Size Price Qty
B1579-5 5 mg
B1579-25 25 mg
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Product Details

Alternate Name  2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester; Aryl hydrocarbon receptor ligand
Appearance Yellow solid
CAS # 448906-42-1
Molecular Formula C₁₄H₁₀N₂O₃S
Molecular Weight 286.3
Purity ≥98% by HPLC
Solubility DMSO (>25 mg/ml)
InChi InChI=1S/C14H10N2O3S/c1-19-14(18)11-7-20-13(16-11)12(17)9-6-15-10-5-3-2-4-8(9)10/h2-7,15H,1H3
PubChem CID 4668801
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). It enhances differentiation of cancer stem-like cells detected by the decrease of sphere formation and proliferation from glioblastoma cells U87. Mechanically, ITE bound AhR inhibits transcription of OCT4, an inducer of pluripotent stem cells, through direct binding to OCT4 promoter. As a consequence, ITE treatment significantly represses the tumor formation in xenograft model using injection of U87 cells.

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