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A soluble guanylyl cyclase activator
Catalog #: 2528
SKU-Size Size Price Qty
2528-5 5 mg
2528-25 25 mg
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Product Details

Alternate Name 1-​(2E,​4-​dihydroxyphenyl)-​3-​(4-​hydroxyphenyl)-​2-​propen-​1-​one; GU 17; ISL
Appearance Yellow to orange solid
CAS # 961-29-5
Molecular Formula C₁₅H₁₂O₄
Molecular Weight 256.26
Purity ≥95% by HPLC
Solubility DMSO (20 mg/ml)
InChi InChI=1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
PubChem CID 638278
MDL Number MFCD00075907
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants. Displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against steatosis-induced oxidative stress. Acts as a soluble guanylyl cyclase activator. Also displays chemoprevention by induction of phase 2 enzymes such as quinone reductase, that protect cells against reactive, toxic, and potentially carcinogenic species.

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