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ISCK03

A cell-permeable Stem-Cell Factor/c-Kit Inhibitor
Catalog #: B2274

In stock

SKU-Size Size Price Qty
B2274-5 5 mg
$85.00
B2274-25 25 mg
$325.00
More Sizes Get Quote

Product Details

Alternate Name 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-benzenesulfonamide
Appearance Crystalline solid
CAS # 945526-43-2
Molecular Formula C₁₉H₂₁N₃O₂S
Molecular Weight 355.5
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C=CN=C3
InChi InChI=1S/C19H21N3O2S/c1-19(2,3)15-4-10-18(11-5-15)25(23,24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14,21H,1-3H3
InChi Key ABBHBFHWHMKF-UHFFFAOYSA-N
PubChem CID 3792751
MDL Number MFCD12031591
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ISCK03 is a cell-permeable Stem-Cell Factor/c-Kit Inhibitor that inhibits c-kit activity (IC₅₀ <2.5 μM in cell-free kinase assays) and blocks SCF-induced c-kit and Erk phosphorylation (1 μM causes >90% inhibition) without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells.


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