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Irisin, Active, human recombinant

Activates beige fat cells
Catalog #: 7852
SKU-Size Size Price Qty
7852-10 10 µg
$295.00
7852-50 50 µg
$945.00
More Sizes Get Quote

Product Details

Alternate Name Fibronectin Type III Domain-containing Protein 5, FNDC5 (cleaved); Fibronectin Type III Repeat-containing Protein 2, FRCP2 (cleaved).
Gene Symbol FNDC5
Gene ID 252995
Accession # Q8NAU1
Source E. coli
Appearance Lyophilized powder
Physical Form Description Lyophilized from PBS.
Molecular Weight ~13.00 kDa
Purity by SDS-PAGE ≥95%
Reconstitution Instructions Reconstitute to 0.1 mg/ml with sterile water
Amino Acid Sequence Full-length untagged Irisin (112 amino acids)
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Irisin is a recently discovered exercise-induced myokine, which is secreted by skeletal muscles and produced by cleavage of the FNDC5. Studies show that Irisin stimulates mitochondria uncoupling protein-1 (UCP-1; a regulator of thermogenic capability of brown fat) expression, so Irisin can upregulate white to brown fat conversion and improve systemic metabolism by increasing energy expenditure. Hence, Irisin is a potential new drug target in the study of metabolic disorders, such as obesity and type 2 diabetes mellitus (T2DM). Moreover, FNDC5-like receptors are conserved in vertebrates and critical for neuronal development.


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