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Irinotecan Hydrochloride

A DNA topoisomerase I inhibitor
Catalog #: 1752
SKU-Size Size Price Qty
1752-50 50 mg
$90.00
1752-250 250 mg
$310.00
More Sizes Get Quote

Product Details

Alternate Name S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo1H-pyrano[3’,4’:6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4’bipiperidine]-1’-carboxylate, Hydrochloride
Appearance Yellow solid
CAS # 100286-90-6
Molecular Formula C₃₃H₃₈N₄O₆. HCl
Molecular Weight 623.14
Purity ≥98% by HPLC
Solubility DMSO (50 mg/ml)
SMILES CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7.Cl
InChi InChI=1S/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0./s1
InChi Key GURKHSYORGJETM-WAQYZQTGSA-N
PubChem CID 74990
MDL Number MFCD01862255
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

An anticancer agent. This is a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I.


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